In our patient the pituitary MRI showed both left and right lesions of 9 mm and 6 mm, respectively: although the radiological finding of the left lesion was suggestive of an ACTH-secreting adenoma, we still preferred to perform bilateral inferior petrosal sinus sampling (BIPSS) [18]: according to the methodology described in the literature, we measured ACTH at baseline and at 3, 5, and 10 minutes after CRH administration. This evidence concerns the gene CRH and adenoma.