Extracellular vesicle-associated tissue factor (TF), the main activator of the coagulation cascade, plays a major role in pathogenesis of the prothrombotic state observed in cancer patients.14 Tissue factor is expressed on non-vascular cells, activated cells within the vessel wall (such as leukocytes and endothelial cells), and circulating EVs. The gene discussed is TF; the disease is cancer.