Thus, apart from the ability of heparinase to increase Xa levels in normal human plasma, a statistically significant positive correlation was found in patients with acute leukemia and healthy donors between the plasma levels of heparanase and Xa.17 Baker et al.18 recently reported that heparanase-over-expressing mice generated a larger thrombus within a shorter period of time compared to control mice in arterial injury and stent occlusion models, supporting the procoagulant effect of heparanase. Here, HPSE is linked to acute leukemia.