While the molecular underpinnings of interactions between glioma cells and coagulation system are still poorly understood, brain tumor cells activate and respond to stimulation with clotting factors (VIIa, IIa) and PAR activating peptides.23,67,102 This property may depend on the availability of the respective receptors such as TF on the cancer cell surface. The gene discussed is TF; the disease is central nervous system cancer.