The control group patients who developed CIN had higher levels of hsCRP, ICAM-1, and P-selectin after PCI, and the reduction of CIN by pretreatment with CDDP was paralleled by a significant decrease in postintervention hsCRP, ICAM-1, and P-selectin levels. The gene discussed is ICAM1; the disease is cervical squamous intraepithelial neoplasia.