APOE and atherosclerosis: Knocking-out Arg-II gene in the atherosclerosis-prone ApoE−/− mice (ApoE−/−/Arg-II−/−) decreases inflammatory cytokine levels and macrophage content in the aortas, reduces atherosclerotic plaque formation, and reveals more stable plaque features as compared to ApoE−/−Arg-II+/+ control mice.