Elevated ghrelin levels induced by chronic exposure to social stress are associated with increased caloric intake and body weight gain in male C57BL/6 mice and minimizes CSDS-associated depression-like behavior whereas stressed mice lacking ghrelin receptors (ghsr−/− mice) or treated i.c.v with ghrelin receptor antagonist [d-Lys3]-GHRP-6 show attenuated weight gain and feeding responses under the same social stress paradigm (41, 132). Here, GHSR is linked to major depressive disorder.