However, whereas transgenic mice lacking CRF-R1 showed a reduced stress response and blunted anxiety-like behaviors (Smith et al., 1998; Timpl et al., 1998), those lacking CRF-R2 exhibited pronounced anxiety-like behaviors and stress hypersensitivity (Bale et al., 2000; Coste et al., 2000). The gene discussed is CRHR2; the disease is Anxiety.