An improvement in insulin sensitivity and mitochondrial function (mitochondrial density and oxidative enzyme activity) was also reported by Toledo et al. (110) in T2D patients after 4 months of exercise training, by Nielson et al. (111) in male T2D subjects after 10 weeks of exercise, and by Meex et al. (112) in T2D patients after a 12-week exercise bout. This evidence concerns the gene INS and type 2 diabetes mellitus.