Since earlier reports found that B cells from active SLE patients were less responsive to TLR9 stimulation in terms of IL-6 and IL-10 production [21], we analyzed the relation between the cytokines from groups 1 and 2 and the disease activity (SLEDAI) by using a heat map (Figure 3A). The gene discussed is TLR9; the disease is systemic lupus erythematosus.