GSK-3β is a serine/threonine protein kinase that has been shown recently to play a key role during the inflammatory response induced by various pathogenic bacteria, such as Francisella tularensis, the causative agent of highly virulent tularemia [31], Burkholderia pseudomallei [32] and group A streptococcus [33]. This evidence concerns the gene AKT1 and tularemia.