From a broad perspective, breast cancer may be subclassified into EMT-associated ER-poor tumors with TP53 dysfunction at one extreme, contrasting with TP53-wildtype ER-rich tumors with predisposing primary defects of the PI3K-Akt-mTOR anti-apoptotic pathway at the other [9]. The gene discussed is AKT1; the disease is breast carcinoma.