MAPT and neurodegenerative disease: However, Aβ and Tau together are often associated with dementia [12] and Tau mutations and/or accumulation are causal to some neurodegenerative diseases that do not display β-amyloid pathology, including FTDP-17, PSP, and CBD, suggesting that Tau associated neurodegeneration can occur independently of plaque deposition [6, 7].