PRRT2 and adenocarcinoma: In the present study we show that gastrin-mediated signalling, known to involve the Gq/G11-coupled CCK2 receptor and signalling pathways like PI3K-PKB/Akt, PKC and MEK-ERK1/2 [29], [31], [43], induces transient SIK1 expression in adenocarcinoma cells.