Interestingly, we found that although Cd155 expression on MCA-induced fibrosarcomas was significantly higher in DNAM-1–deficient mice than in WT mice, Cd112 expression was similar, suggesting that CD155, rather than CD112, is the tumor ligand involved in DNAM-1–mediated immune surveillance against MCA-induced fibrosarcoma. This evidence concerns the gene CD226 and fibrosarcoma.