There was also a significant main effect of menstrual cycle on the state anxiety (F = 16.459, R2 = 0.098, P<0.001), Beck Anxiety Inventory (F = 60.690, R2 = 0.287, P<0.001), Beck Depression Inventory (F = 28.713, R2 = 0.160, P<0.001), and Pain Catastrophizing Scale (F = 4.514, R2 = 0.030, P = 0.035) scores and a significant main effect of BDNF genotype on the state anxiety (F = 6.207, R2 = 0.039, P = 0.014) and Beck Anxiety Inventory (F = 4.974, R2 = 0.032, P = 0.027) scores. This evidence concerns the gene BDNF and major depressive disorder.