HIF1A and neoplasm: As an important transcriptional factor, the accumulation of HIF-1α may affect multiple signaling pathways and regulate various biological functions, such as inducing autophagy [42], [43], promoting tumor cell invasion and metastasis [44]–[46] and protecting cells of the brain, liver, kidney and heart from cellular oxidative stress and ischemia/reperfusion-induced injury [47]–[49].