Moreover, many mutations associated with the inheritance of LCA have been described and used to differentiate the subtypes of LCA1∼15, for instance, GUCY2D (LCA1), RPE65 (LCA2), AIPL1 (LCA4), RPGRIP1 (LCA6), CRX (LCA7), and CRB1 (LCA8) (http://wwww.ncbi.nlm.nih.gov/omim). This evidence concerns the gene RPE65 and Leber congenital amaurosis.