ANK1 and Brugada syndrome: We noted that Glu1112, which is completely conserved in both Na+ and K+ channels and mutation of which in Nav1.5 to Lys is known to cause Brugada syndrome in humans (Mohler et al., 2004), occupies the identical position as Glu1622 of AS does in the ANK repeats/AS complex (Figure 3A and Figure 6A,E).