In fact, some literature data underline the possible pathogenetic role of anti-mitochondrial reactivity per se via molecular mimicry [11]–[13], [17]–[19], and a meta-analysis on the role of CTLA-4 SNP (+49A/G) as a predisposing factor in PBC suggests, though circumstantially, a link with AMA positivity [34]. Here, CTLA4 is linked to primary biliary cholangitis.