First of all, they are reminiscent of similar observations reported by a number of research groups, including our own, in other autoimmune diseases (both systemic and organ-specific) [26]–[31], [33], [34], and in other immunological or haematological disorders, such as IgE-mediated reaction to hymenoptera venom [35], or acute lymphoblastic leukemia (ALL) in paediatric patients [36]. The gene discussed is IGHE; the disease is autoimmune disease.