Given that lack of SOCS1 leads to hyper-activation of DCs in HIV, we ask the question whether reducing expression of SOCS1 will facilitate an effective immune response against fungi such as C. albicans. To better understand the implication of SOCS1 on DCs and immune regulation in response to fungal infection, we utilize murine bone marrow DCs to characterize the immune response by means of siRNA-mediated reduction in SOCS1 mRNAs. Here, SOCS1 is linked to fungal infectious disease.