Consistent with these data, we also confirmed, by using immunofluorescence microscopy and a spectrophotometry-based technique, a reduction in the CD31 (Fig. 1B,C) and hemoglobin (Fig. 1D) content of sponges from diabetic mice, indicating that the processes involved in capillary formation in connection with blood vessel function are attenuated during the course of diabetes. Here, PECAM1 is linked to diabetes mellitus.