More intriguingly, it also ameliorated diabetes-related defects in VEGF promoter responsiveness to MB-cAMP (Fig. 6Da, MB-cAMP 16 hours), as well as in the expression of this growth-promoting polypeptide, both at the mRNA (Fig. 6Db, MB-cAMP 6 hours) and protein levels (Fig. 6Dc, MB-cAMP 24 hours). This evidence concerns the gene VEGFA and diabetes mellitus.