A combination of proteomic and genomic analyses of 243 GBM from The Cancer Genome Atlas (TCGA), subdivides these tumors into three subclasses based on the pattern of expression and genetic alterations: classical/EGFR+, proneural/PDGFR + and mesenchymal/NF1+ classes[12]. The gene discussed is EGFR; the disease is glioblastoma.