A study on 196 cases of GBM from the TCGA consortium, reports that the expression of Notch signaling components was enriched in the classical/proliferative GBM subtype characterized by EGFR+/PDGFRA- and in the proneural subtype, characterized by PDGFRA+/IDH1+[38], indeed we did find these correlations in our GBM CSC. The gene discussed is IDH1; the disease is glioblastoma.