At 3 months, fructose feeding induced upregulation of several genes coding nuclear factors (Rxrg, Nr1h3, p≤0.1), proteins involved in lipid metabolism including Pltp (p≤0.1), Lcat, and Cd36 (p≤0.05), cell death inflammation (Tnf, p≤0.1), and diabetes (Irs1, Slc2a2, p≤0.1). The gene discussed is IRS1; the disease is diabetes mellitus.