In glioma andmedulloblastoma cell lines, knockdown of Msi1 reduced thecolony-forming capacity of these cells and reduced their tumorigenic growth in axenograft assay in mice (Muto et al., 2012).Msi expression correlates with HER2 expression in breast cancer cell lines, andknockdown of Msi proteins resulted in decreased proliferation (Wang et al., 2010). This evidence concerns the gene ERBB2 and breast cancer.