To test whetherectopic expression of Msi in mesenchymal cancer cells can promote an epithelialstate, we overexpressed Msi1 in the mesenchymal cell line MDAMB231,where Msi1 levels are extremely low.Msi1-overexpressing cells had decreased mesenchymal markerexpression and increased levels of epithelial marker expression (Figure 6B), consistent with promotion of the epithelial state.We conclude that Msi activation promotes the epithelial state in breast cancercells. Here, MSI1 is linked to cancer.