TP53 and neoplasm: The observation thatMsi1/Msi2 was not significantly mutated in mosttumors but are overexpressed in several tumor types (including glioblastoma) makestheir profile more similar to oncogenes like FOS or HER2, than to tumor suppressorslike PTEN and TP53, which tend to have the opposite pattern (Verhaak et al., 2010; CancerGenome Atlas Network., 2012) (Figure1B).