Figure 4 is a heatmap comprising the mean expression of the 16 genes organized into three classes. The first class (orange) is expressed in non-IR cases and may reflect the activity of immunosuppressive elements. The second set (purple) is expressed in IR cancers but is unrelated to prognosis. The third (cyan) is expressed strongly in IR cases with good prognosis and may indicated immune stimulatory effects. A viable hypothesis might be to see if T cells responding to the second set of antigens (ZNF165, CEP55, ATAD2, MAGEZ3, CTAGE5) have regulatory phenotypes. This evidence concerns the gene CEP55 and cancer.