MYC and neoplasm: While higher c-Myc mRNA expression levels correlated with response to treatment, a non significant correlation was found in our study between c-Myc mRNA overexpression in the tumor and c-Myc gene amplification, suggesting that overexpression of c-Myc also can occur via mechanisms independent of gene amplification [25], such as chromosomal translocations [26], point mutations in the coding sequence of the promoter region [27]–[30], or activation/deactivation of trans-activating factors.