To evaluate the capacity of microbiota-derived TLR ligands to induce cell shedding and mucosal damage, a sublethal dose of LPS, or Polyinosinic polycytidylic acid (poly(I:C)), an immunostimulant that simulates viral infection and interacts with TLR3 was injected intraperitoneally into wild-type mice. The gene discussed is TLR3; the disease is viral infectious disease.