Depletion of CIB1 in endothelial cells results in decreased PAK1 activation and impaired endothelial cell function [5], [6], and we have previously reported that CIB1−/− mice exhibit impaired ischemia-induced angiogenesis in retinal and hindlimb tissue concomitant with a decrease in PAK1 activation [5]. The gene discussed is PAK1; the disease is ischemia.