It has been consistently reported that miRNAs may regulate haemostatic proteins such as fibrinogen [22], tissue factor [23], PAI-1[24] or antithrombin [21], while variations in the levels of miRNAs [23] or in the efficacy of the miRNA: mRNA interaction [27] might have an impact on the development of thrombotic diseases. This evidence concerns the gene SERPINE1 and thrombotic disease.