MAPK3 and microcephaly: KCTD13 (potassium channel tetramerization domain containing 13) was revealed recently by Golzio et al [32] as a major driver for the neurodevelopmental phenotypes associated with the 16p11.2 CNV, and 16p11.2 duplication was associated with microcephaly phenotype in zebrafish embryos with MAPK3 and MVP named as possible modifiers.