KCTD13 (potassium channel tetramerization domain containing 13) was revealed recently by Golzio et al [32] as a major driver for the neurodevelopmental phenotypes associated with the 16p11.2 CNV, and 16p11.2 duplication was associated with microcephaly phenotype in zebrafish embryos with MAPK3 and MVP named as possible modifiers. Here, MVP is linked to microcephaly.