INS and Insulin resistance: De Bock et al. [17] also found a 15%–20% improvement in insulin sensitivity, compared with placebo, following 12 weeks of daily supplementation with 380 mg of olive leaf extract (containing 51.1 mg of oleuropein) in overweight men with borderline insulin resistance (mean Matsuda Index = 5.12; Matsuda Index <4.3 indicates insulin resistance).