PRKN and Parkinson disease: Additionally, 4-PBA alleviates ER stress by the Pael receptor, which is thought to be accumulated in PARK2, one type of inherited Parkinson's disease [72], reduced the area of damage due to ischemia in a rat model of cerebral infarction [73], it has been found to prolong life [74], and contribute to therapy for spinal muscular atrophy [75] by altering the pattern of gene expression.