Similarly, El-shehaby et al. (2010) [18] found that acylated ghrelin levels showed negative correlations with serum albumin and prothrombin concentration and positive correlations with total and direct bilirubin, which indicates that the biologically active form of ghrelin is more correlated with severity of CLD. The gene discussed is F2; the disease is congenital secretory chloride diarrhea 1.