INS and diabetes mellitus: The prototypical 2,4-thiazolidinedione, ciglitazone 47 was discovered [63] by Takeda Chemical Industries, Ltd., Japan, and has antihyperglycemic activity in insulin-resistant animal models, KKAy mice [64], and Wistar fatty rats [65] but no effect in insulin-deficient animal models of diabetes [66, 67].