BRAF and pancreatic neoplasm: This observation is consistent with three recent studies: Firstly, Haq et al. reported that BRAF inhibitor-resistant cells are more addicted to OXPHOS [32]; secondly, Roesch et al. demonstrated that the multi-drug resistant JARID1Bhigh subpopulation of melanoma cells expressed more OXPHOS enzymes [33]; and most recently, Viale et al. showed that pancreatic tumor cells surviving oncogene ablation depend on mitochondria [34].