Bacteria- specific IgE has been reported in 57% of patients with CRS as compared to only 10% in subjects with allergic rhinitis [173] and bacteria like Staphylococcus aureus possess the ability to elicit exotoxins, and superantigens can activate subpopulations of the T-lymphocytes (5-30%) [174]. The gene discussed is IGHE; the disease is congenital rubella syndrome.