Bacterial superantigens in the pathogenesis of CRSwNP, superantigen production, and host T-lymphocyte response are crucial components of common chronic eosinophilic-lymphocytic respiratory mucosal disorders [175] and staphylococcal superantigen-specific IgE antibodies to the superantigens SEA and SEB have been detected in nasal polyp tissue [176]. The gene discussed is IGHE; the disease is chronic rhinosinusitis with nasal polyps.