Although Caucasian CRSwNP is characterized by a predominant Th2-type eosinophilic inflammation with high levels of IL-5, ECP and local IgE, and Asian CRSwNP preferentially has a Th1/Th17 polarization signature, typical remodeling features in nasal polyps from both ethnic groups are albumin accumulation and edema (pseudocyst) formation within the extracellular matrix. The gene discussed is RNASE3; the disease is Nasal polyposis.