Also histopathological findings of asthma, including epithelial shedding and basement membrane thickening features of airway remodeling, eosinophillic infiltration, T helper cell involvement and interleukin 5 production, as well as IgE formation are present in CRS and asthma [270, 273], suggesting similar pathological processes in CRS and asthma. Here, IGHE is linked to congenital rubella syndrome.