Although the development of CRS has been reported to be associated with a variety of cytokines (including IL1α [46–48], TNFA [47–49], IL1B [47, 50], IL10 [50, 51], IL33 [52], TGFB1 [53], TNFA1P3 [54], IL4 [55], TSLP [56]), cytokine receptors (IL1RN [57], IL22RA1 [58], IL1RL1 [59], MET [60, 61]), immunity pathways (SERPINA1 [62, 63] TLR2 [64]. Here, IL22RA1 is linked to congenital rubella syndrome.