IGHE and chronic rhinosinusitis with nasal polyps: More recently, Gevaert et al demonstrated RAG1 and RAG2 mRNA concentrations are increased in CRSwNP and correlated with the magnitude of inflammation and the presence of S. aureus enterotoxin (superantigen)-specific IgE in the nasal polyp mucosa confirming local receptor revision and class switching to IgE, and B-cell differentiation into IgE-secreting plasma cells in CRSwNP [169].