Immunoglobulins like IgA, IgE, IgG and IgM are also increased in polyp fluid and tissue [177] and the concentrations of total IgE, IL-5, eotaxin, ECP, LTC4/D4/E4, and sCD23 were significantly higher in nasal polyp tissue as compared with non-polyp tissue [180]. This evidence concerns the gene CD40LG and polyp.