HNF1B and Familial prostate cancer: SNP rs4403796 is an eQTL (expression quantitative trail locus) associated with decreased HNF1B mRNA expression in benign prostate tissue (the at-risk tissue for prostate cancer) (3), while the serous ovarian cancer subtype lead risk SNP rs7405776 is an methylation quantitative trait locus (mQTL) associated with decreased expression in serous ovarian tumor tissue.