Ichthyosis vulgaris (MIM 146700) and atopic dermatitis (ATOD2; MIM 605803) can be associated with loss-of-function mutations in the filaggrin gene (FLG; Smith et al. 2006; Palmer et al. 2006; Weidinger et al. 2006). The gene discussed is FLG; the disease is ichthyosis vulgaris.