SLC16A1 and neoplasm: Interestingly, lactate released as a waste product of glycolytic energy production in hypoxic tumor microenvironment has been demonstrated to constitute a prominent substrate that fuels the oxidative metabolism of tumor cells in oxygenated regions, and MCT1 has been shown to be involved in lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilized lactate for oxidative metabolism [78].