However, it remains to be seen whether these findings can be applied to MSCs; that is, whether MSCs can be induced to upregulate COL7A1 expression, and furthermore whether increased COL7A1 expression can be coupled with enhanced MSC migration and immunosuppression as a model for improved transplantation efficacy in RDEB. This evidence concerns the gene COL7A1 and recessive dystrophic epidermolysis bullosa.