VDR but also CYP27B1 KO mice have high BP levels and cardiac hypertrophy due to increased activation of the renin-angiotensin system (RAS) [69], and calcitriol treatment inhibits renin activation and decreases BP and cardiac hypertrophy in CYP27B1 KO mice [70]. The gene discussed is CYP27B1; the disease is cardiac hypertrophy.