ESR2 and metastatic colorectal cancer: Recent studies on prognosis observed that men with metastatic colorectal cancer harbouring two long alleles of the ESR2 CA repeat had poorer overall and progression-free survival than men with short alleles [17] and women with metastatic colon cancer harbouring two long alleles had a significantly reduced risk of dying compared to women with at least one short allele [18].