The ESR2 repeat polymorphism (having two alleles of ≥25 CA repeats versus 24 CA repeats) was previously reported to be associated with increased risk of colon cancer among women, but not among men (OR women = 2.1 95% CI 1.2 - 3.6, OR men =1.0, 95% CI 0.6 - 1.6, p heterogeneity =0.03) [16]. This evidence concerns the gene ESR2 and malignant colon neoplasm.