Transition cells that were barely detected in the glomerular tuft at baseline in SM22α +/+ or -/- mice (13.19 ± 3.09, vs. 23.53 ± 5.95 PAX2+/Synaptopodin+ cells/mm2 of glomerular tuft; P = 1.00 ), increased in glomerular disease. The gene discussed is PAX2; the disease is glomerular disorder.