However, in experimental glomerular disease, the number of PAX2 positive cells in the tuft increased, but was significantly higher in SM22α -/- mice compared to SM22α +/+ mice at day 14 (303.13 ± 41.07 vs. 576.51 ± 55.52; P <0.01) (Figure 1C). Here, PAX2 is linked to glomerular disorder.