Although hematopoietic stem cell transplantation [35–37], kidney transplantation [38, 39], juvenile idiopathic arthritis [40], and chronic beryllium disease [41, 42] have been reported to be related to HLA-DP after 2000, HLA-DP had never been investigated for its relationship with HBV disease before a GWAS study identified the close association between HLA-DP and HBV infection in Asians. This evidence concerns the gene HLA-DPB1 and juvenile idiopathic arthritis.