The solubility, stability, and the CN- binding ability of cobalamin derivatives depend on the type of the β-axial ligand and the presence or lack of 5,6-dimethylbenzimidazole at the α-axial ligand [10]–[16] The presence of this group in Cbi causes the increased binding ability to CN- (100 times greater than Cbl), explaining the difference of Cbi as compared to Cbl in CN- detoxification of massive CN- poisoning [17], [18]. The gene discussed is CBL; the disease is poisoning.