This was also reflected in the KEGG pathway analysis of trans-mQTLs (Table S10) where type 1 diabetes was found to be an enriched pathway of relevance in human pancreatic islets, including the following genes: PTPRN2, HLA-DRB1, HLA-B, HLA-C, HSPD1 and HLA-DRB5 (Padj = 6.0×10−4). This evidence concerns the gene HLA-DRB1 and type 1 diabetes mellitus.