NR3C2 and Increased circulating aldosterone concentration: As the affinity of mineralocorticoid receptors for glucocorticoids and aldosterone is similar [14], the presence of higher concentrations of active glucocorticoids—as occurs with GA-induced suppression of 11β-HSD 2 [14]—could lead to their competitive binding to mineralocorticoid receptors, leading to a syndrome of apparent mineralocorticoid excess [14,15,16].