The important point from the current study, with respect to the potential safety of orally-administered GA, is that while high sucrose diets lead to increased blood pressure, likely involving effects of hyperinsulinemia, GA—with its known effects on glucocorticoid balance—does not further exacerbate HSD-induced hypertension, when administered with the current dosing paradigm. The gene discussed is CHST3; the disease is hypertensive disorder.