Though previous results showed stability of IFI16 in HSV-1-infected U2OS cells up to 12 h [44], IFI16 protein was decreased 80% in wt-U2OS cells (Figure 6B, lane 4 compared with lane 1) and 87% in IFI16-transduced clone 67 cells (Figure 6B, lane 6 compared with lane 3) after a 24 h infection with HSV-1 at an moi of 1 pfu/cell. Here, IFI16 is linked to infection.