Moreover, a dynamic co-regulation of PGC-1α with DCN (decorin), a tumor suppressor gene evoking mitophagy, has been demonstrated in breast carcinoma.37 Also, in the same work, the signaling pathway and the specific role of PGC-1α in governing mitophagy remains elusive and limited to cancer cells. This evidence concerns the gene PPARGC1A and breast carcinoma.